Cancer Research 2011 VOL. 71 NO. 24

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Priority Reports

人类癌症5-羟甲基胞嘧啶严重耗竭，但其水平与IDH1突变并无相关

5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

Reviews

Pax -5基因：B细胞分化和肿瘤疾病的多能调节基因

The Pax-5 Gene: A Pluripotent Regulator of B-cell Differentiation and Cancer Disease

肿瘤生物学和血管修复中内皮调节模式的演变

The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair

Integrated Systems and Technologies

代谢组学分析揭示膀胱癌进展的潜在标志物和生物过程改变

Metabolomic Profiling Reveals Potential Markers and Bioprocesses Altered in Bladder Cancer Progression

通过确定与人类原代癌症的分子相似性选择临床相关癌症细胞系的框架

A Framework to Select Clinically Relevant Cancer Cell Lines for Investigation by Establishing Their Molecular Similarity with Primary Human Cancers

定量分析血管生成在胶质瘤恶性进展中的作用：计算机建模与成像和组织学的整合

Quantifying the Role of Angiogenesis in Malignant Progression of Gliomas: In Silico Modeling Integrates Imaging and Histology

人类乳腺癌原位模型雌激素受体的在体磁共振成像

In Vivo Magnetic Resonance Imaging of the Estrogen Receptor in an Orthotopic Model of Human Breast Cancer

Microenvironment and Immunology

树突状细胞内陷CD8 T细胞α-半乳糖神经酰胺诱导抗肿瘤CD8 + T细胞反应

Dendritic Cell Internalization of α-Galactosylceramide from CD8 T Cells Induces Potent Antitumor CD8 T-cell Responses

免疫治疗靶向作用于常见癌症细胞表面蛋白多糖CSPG4的scFv - FC抗体的功能特性

Functional Characterization of an scFv-Fc Antibody that Immunotherapeutically Targets the Common Cancer Cell Surface Proteoglycan CSPG4

PGE 2诱导的CXCL12生成和CXCR4表达可控制卵巢癌环境中人MDSCs的蓄积

PGE₂-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment

缺氧通过增加ADAM10的表达诱导癌症细胞逃逸天然免疫：一氧化氮的作用

Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide

肽共轭PAMAM树形分子作为通用DNA疫苗平台靶向作用于抗原呈递细胞

Peptide-Conjugated PAMAM Dendrimer as a Universal DNA Vaccine Platform to Target Antigen-Presenting Cells

T细胞表达Smad7可防止结肠炎相关癌

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

Molecular and Cellular Pathobiology

PAX3 - FOXO1诱导大麻素受体-1可增强细胞侵袭和转移

PAX3-FOXO1 Induces Cannabinoid Receptor 1 to Enhance Cell Invasion and Metastasis

雄激素受体和营养信号转导途径协调前列腺癌进展过程中氨基酸转运增加的需求

Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression

p53反应性miR-194抑制凝血酶敏感蛋白-1并促进结肠癌血管生成

p53-Responsive miR-194 Inhibits Thrombospondin-1 and Promotes Angiogenesis in Colon Cancers

乙肝病毒表面抗原通过激活Src/PI3K/Akt途径促进肝脏癌变

Hepatitis B Virus Large Surface Antigen Promotes Liver Carcinogenesis by Activating the Src/PI3K/Akt Pathway

ErbB2诱导的乳腺肿瘤启动和进展过程中细胞周期蛋白D3补偿Cyclin D1的表达减少

Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression

溶酶体跨膜蛋白LAPTM4B促进癌细胞自噬和代谢应激耐受性

Lysosomal Transmembrane Protein LAPTM4B Promotes Autophagy and Tolerance to Metabolic Stress in Cancer Cells

微管和线粒体相关MAP1S增强自噬可抑制基因组不稳定和肝癌形成

Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis

血管生成素样蛋白2是炎性癌变和转移的重要促进因子

Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis

碳酸酐酶IX磷酸化控制其调节缺氧肿瘤胞外酸化的能力

Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors

Prevention and Epidemiology

6p21.3的HSPA1B 变异与中国人群肺癌风险和预后相关

Variations in HSPA1B at 6p21.3 Are Associated with Lung Cancer Risk and Prognosis in Chinese Populations

胶质瘤易感基因位点的全基因组高密度SNP连锁搜索：Gliogene协会的研究结果

Genome-Wide High-Density SNP Linkage Search for Glioma Susceptibility Loci: Results from the Gliogene Consortium

Therapeutics, Targets, and Chemical Biology

miR-221沉默可阻断肝癌并提高存活率

miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival

Sorcin通过调节Ca2 + 稳态诱导人类结直肠癌耐药表型

Sorcin Induces a Drug-Resistant Phenotype in Human Colorectal Cancer by Modulating Ca²⁺ Homeostasis

Wnt信号抑制剂筛选揭示癌症β- Catenin信号的铁依赖性

Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

双IGF-1R/InsR抑制剂BMS-754807与激素药物联合对于治疗雌激素依赖型乳腺癌具有协同作用

Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer

凝血酶敏感蛋白- 1触发细胞迁移和晚期前列腺肿瘤的发展

Thrombospondin-1 Triggers Cell Migration and Development of Advanced Prostate Tumors

一类新的抗癌化合物磷酸非甾体抗炎药的化疗属性

Chemotherapeutic Properties of Phospho-Nonsteroidal Anti-Inflammatory Drugs, a New Class of Anticancer Compounds

胶质母细胞瘤产生的表皮生长因子受体羧基末端缺失突变体在EGFR定向治疗下发生转化并对其敏感

Glioblastoma-Derived Epidermal Growth Factor Receptor Carboxyl-Terminal Deletion Mutants Are Transforming and Are Sensitive to EGFR-Directed Therapies

SMAC类似物（JP1201）以IAP依赖而非TNF-α依赖方式增加非小细胞肺癌对多种化疗药物的敏感性

SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner

Tumor and Stem Cell Biology

GLIPR1通过定向破坏癌蛋白抑制前列腺癌发展

GLIPR1 Suppresses Prostate Cancer Development through Targeted Oncoprotein Destruction

选择素配体Sialyl-Lewis x 抗原驱动激素依赖性乳腺癌转移

Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

肿瘤抑制因子miR-200在调节肿瘤上皮-间质转化中的作用靶点

Targets of the Tumor Suppressor miR-200 in Regulation of the Epithelial–Mesenchymal Transition in Cancer

Meeting Reports

癌症PI3K/mTOR信号的靶向作用

Targeting PI3K/mTOR Signaling in Cancer