Blood 2011 VOL. 118 NO. 26

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PLENARY PAPER

诱导移植物抗宿主病的异基因HLA反应性T细胞具有特异性单肽特征

Allo-HLA–reactive T cells inducing graft-versus-host disease are single peptide specific

REVIEW ARTICLE

内皮选择素白细胞配体：在流动的情况下的一种专门的可调节细胞滚动及信号的糖复合物

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

CLINICAL TRIALS AND OBSERVATIONS

慢性淋巴细胞白血病中的SF3B1剪接因子突变：与进展和氟达拉滨无反应的相关性

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

唐氏综合症的新生儿中临床诊断为一过性骨髓增生症的自然史：来自儿童肿瘤组A2971研究的报告

Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971

利妥昔单抗可在治疗过程中或治疗后6个月内阻断淋巴瘤患者A型流感（H1N1）2009疫苗的保护性血清学反应

Rituximab blocks protective serologic response to influenza A (H1N1) 2009 vaccination in lymphoma patients during or within 6 months after treatment

ASXL1突变可在ELN有益遗传分类内确定一种原发性细胞遗传学正常的AML老年患者高风险亚群

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

另外的细胞遗传学异常对慢性粒细胞白血病预后的影响：随机慢性粒细胞白血病IV研究1151例患者长期观察

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV

HEMATOPOIESIS AND STEM CELLS

粒细胞生成中具有的细胞自主性和非细胞自主性ADAM10活性双功能

Dual functions of cell-autonomous and non–cell-autonomous ADAM10 activity in granulopoiesis

IMMUNOBIOLOGY

高细胞密度下预培养外周血单核细胞可提高T细胞反应的灵敏性，这揭示在CD28超拮抗剂 TGN1412的作用下出现细胞因子释放

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

IL - 21是体内人B细胞分化所需的一种主要的共同γ链结合细胞因子

IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo

STAT4蛋白表达的microRNA调节：人自然杀伤细胞的IL - 12信号的快速，灵敏调节

MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells

恶性疟原虫红细胞周期控制：γδT细胞以裂殖子侵入的红血细胞为靶向

Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell–invasive merozoites

B细胞复制史和体细胞超突变状态可确定共同多样性免疫缺陷情况下的不同病理生理背景

B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency

单核细胞分化为树突状细胞过程中，人巨细胞病毒可抑制GM - CSF旁分泌信号

Paracrine inhibition of GM-CSF signaling by human cytomegalovirus in monocytes differentiating to dendritic cells

恒河猴持续输注IL – 15可诱导外周血CD8 +效应记忆群的大规模增殖

IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood

TLR配体定向传输给人和小鼠树突状细胞可显著增强佐剂的作用

Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity

mTORC1和mTORC2可差异性调节人肿瘤和非肿瘤性肥大细胞的动态平衡

mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells

小鼠消融期巨噬细胞的转录分析

Transcriptomic analyses of murine resolution-phase macrophages

LYMPHOID NEOPLASIA

FTY720可增加CD74表达并使套细胞淋巴瘤细胞对米拉珠单抗介导的细胞死亡敏感

FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death

多发性骨髓瘤中TORC1 / 2作用的界定

Defining the role of TORC1/2 in multiple myeloma

MIR - 135B可介导NPM- ALK驱动的致瘤性，并导致IL – 17对间变性大细胞淋巴瘤产生免疫表型

miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma

EBV相关性和非EBV相关性Burkitt淋巴瘤小鼠模型的一种共享基因表达谱

A shared gene expression signature in mouse models of EBV-associated and non–EBV-associated Burkitt lymphoma

多发性骨髓瘤疾病患者骨髓基质干细胞中表达的Gfi1是一种新型成骨细胞抑制基因

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

MYELOID NEOPLASIA

Δ12-前列腺素 J3，一种ω- 3脂肪酸衍生代谢产物，可选择性杀灭小鼠白血病干细胞

Δ12-prostaglandin J3, an omega-3 fatty acid–derived metabolite, selectively ablates leukemia stem cells in mice

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Cpa3 - Cre重组; Mcl-1fl/fl小鼠的肥大细胞和嗜碱性粒细胞数目减少和功能下降

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

RED CELLS, IRON, AND ERYTHROPOIESIS

戴-布二氏贫血的核糖体蛋白基因缺失

Ribosomal protein gene deletions in Diamond-Blackfan anemia

THROMBOSIS AND HEMOSTASIS

在凝血酶存在的情况下，聚磷酸铵是因子XI的一种激活辅助因子

Polyphosphate is a cofactor for the activation of factor XI by thrombin

TRANSPLANTATION

色氨酸分解代谢与人造血干细胞移植后急性移植物抗宿主病有关，并提示吲哚胺2,3 - 双加氧酶的激活

Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase

VASCULAR BIOLOGY

Etv2/ER71可诱导Flk1 +PDGFRα+原始中胚层出现血管中胚层

Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm