Cancer Research 2012 VOL. 72 NO. 2

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Priority Reports

提高血液灌注的抗血管生成疗法治疗有效的胶质母细胞瘤患者生存率升高

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

应激调节转录因子ATF4通过抑制INK4a/ARF细胞衰老因子的表达可促进恶性转化

Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell Senescence Factors

Reviews

转移相关蛋白1/Nucleosome重塑与癌症组蛋白脱乙酰基酶复合物

Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer

jNK诱导的细胞凋亡，补偿性生长与癌症干细胞

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

Clinical Studies

氧化应激相关基因的遗传变异可预测原发性乳腺癌的耐药：一项前瞻性观察性研究和验证

Genetic Variants in Oxidative Stress–Related Genes Predict Chemoresistance in Primary Breast Cancer: A Prospective Observational Study and Validation

Microenvironment and Immunology

粒蛋白A可调节肿瘤自播种和传播

Chromogranin A Regulates Tumor Self-Seeding and Dissemination

IL – 10敲除可促进肿瘤形成，生长和转移

Interleukin-10 Ablation Promotes Tumor Development, Growth, and Metastasis

血小板衍生的MHC I类分子可引起癌细胞的一种假性表型，该表型颠覆了自然杀伤免疫细胞的抗肿瘤反应

Platelet-Derived MHC Class I Confers a Pseudonormal Phenotype to Cancer Cells That Subverts the Antitumor Reactivity of Natural Killer Immune Cells

肿瘤抑制性小分子RNA miR - 34A / C可控制癌症细胞表达一种应激诱导自然杀伤细胞受体NKG2D配体ULBP2

Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

肿瘤冷冻联合抗CTLA - 4治疗可有效诱导肿瘤免疫

Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti–CTLA-4 Therapy

Molecular and Cellular Pathobiology

三氧化二砷治疗可减少肿瘤细胞的耗氧率和增敏实体瘤放疗疗效

Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors

JNK酶在乳腺发育和乳腺癌中的作用

Role of JNK in Mammary Gland Development and Breast Cancer

乳酸酸中毒和缺氧反应的相互作用可调节基因转录输出

Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs

Prevention and Epidemiology

PSA检测前列腺癌中的循环胰岛素样生长因子和IGF结合蛋白研究：一项大型病例对照保护研究

Circulating Insulin-Like Growth Factors and IGF-Binding Proteins in PSA-Detected Prostate Cancer: The Large Case–Control Study ProtecT

Therapeutics, Targets, and Chemical Biology

化学去势可引起前列腺向上皮 - 间质转型：化学去势治疗的影响

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy

E2F转录因子对基质金属蛋白酶基因的调节：Rb - Raf - 1相互作用可作为转移性疾病的新靶点

Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb–Raf-1 Interaction as a Novel Target for Metastatic Disease

Tumor and Stem Cell Biology

透明质酸合成酶HAS2可通过刺激巨噬细胞与基质细胞和乳腺癌的相互作用促进骨肿瘤进展

Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem–Like Cells with Macrophages and Stromal Cells

P53可负性调控丙酮酸脱氢酶激酶Pdk2的转录

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

类固醇受体辅激活因子SRC – 1可引起转移性进展且对芳香酶抑制剂耐药

Metastatic Progression with Resistance to Aromatase Inhibitors Is Driven by the Steroid Receptor Coactivator SRC-1