Blood 2012 VOL. 119 NO. 04

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REVIEW ARTICLE

组织因子和癌症进展之间的关系：来自科研和临床的顿悟

The relationship between tissue factor and cancer progression: insights from bench and bedside

PI3/PKB信号模块是造血作用的关键调节器：对白血病治疗的重要意义

The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia

CLINICAL TRIALS AND OBSERVATIONS

抗凝血药对动脉局部缺血性脑卒中儿童的安全性

Safety of anticoagulants in children with arterial ischemic stroke

霍奇金淋巴瘤治疗进展：一项基于1973-2009间瑞典确诊患者人口的研究

Progress in Hodgkin lymphoma: a population-based study on patients diagnosed in Sweden from 1973-2009

自体干细胞移植前后使用硼替佐米可改善17P缺失的多发性骨髓瘤患者的结局

Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p

阿司匹林或依诺肝素对新诊多发性骨髓瘤来那度胺治疗患者的防血栓作用

Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide

GENE THERAPY

围产期AAV介导的基因转移导致特定水平基因表达防护致命的自发性出血

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage

IMMUNOBIOLOGY

淋巴结B淋巴细胞输送受解剖学约束并对趋化物的脱敏作用具有高度依赖性

Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization

TLR3极大地促进造血干细胞移植患者MHC-I类限制的记忆性CD8+T细胞对烟曲霉菌的响应率

TLR3 essentially promotes protective class I–restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

LYMPHOID NEOPLASIA

小鼠浆细胞瘤前体和旁观者细胞总基因谱分析揭示浆细胞瘤形成的有力干预靶标

Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia

棕榈酰化/去棕榈酰化周期抑制可选择性减弱表达致癌性Nras的造血细胞的生长

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

组蛋白脱乙酰酶抑制剂是EBV潜伏期基因表达的有效诱因并使淋巴瘤细胞对核苷抗病毒药过敏

Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents

FGFR2基因型及霍奇金淋巴瘤患者的照射相关乳腺癌风险

FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma

三体性12和GLI1、PTCH1转录水平升高是CLL Hedgehog抑制物响应性的生物标记物

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL

PLATELETS AND THROMBOPOIESIS

血小板TGFβ1对压力过载小鼠模型血浆TGFβ1、心肌纤维化和收缩期功能障碍的作用

Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

巨核细胞特异性RhoA不足引起巨血小板减少症和止血时血小板活化不全及血栓形成

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

RED CELLS, IRON, AND ERYTHROPOIESIS

人幼红细胞脱核与非肌肌球蛋白IIB有关

Enucleation of human erythroblasts involves non-muscle myosin IIB

AUF-1和YB-1是红系细胞β球蛋白mRNA表达的关键决定子

AUF-1 and YB-1 are critical determinants of β-globin mRNA expression in erythroid cells

TRANSPLANTATION

供体树突细胞和T细胞之间的IFN-γ、吲哚胺2,3-二氧化酶信号通路调节移植物的抗宿主反应和抗白血病作用

IFN-γ and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity