Cancer Research 2012 VOL. 72 NO. 4

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Reviews

肥大细胞靶向治疗前列腺癌不佳的一面

The Dark Side of Mast Cell–Targeted Therapy in Prostate Cancer

β内啡肽神经元调控癌症进展

Regulation of Cancer Progression by β-Endorphin Neuron

Clinical Studies

N-myc基因可调控解毒酶谷胱甘肽转移酶GSTP1-----神经母细胞瘤预后不良的一种标记物的表达

N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma

Integrated Systems and Technologies

超极化13C光谱法可检测血管内皮生长因子中和治疗后的早期肿瘤血管和代谢变化

Hyperpolarized ¹³C Spectroscopy Detects Early Changes in Tumor Vasculature and Metabolism after VEGF Neutralization

Microenvironment and Immunology

免疫抑制分子LAG-3，PD-1可协同调节T细胞的功能以促进肿瘤免疫逃逸

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

转移性细胞可通过增加自分泌IL-6/STAT3信号来逃脱肿瘤坏死因子-α的凋亡影响

Metastatic Cells Can Escape the Proapoptotic Effects of TNF-α through Increased Autocrine IL-6/STAT3 Signaling

肿瘤微环境可通过上调抑制性受体BTLA的PD-1来导致肿瘤抗原特异性CD8 + T细胞功能失调

CD8⁺ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1

miR-17-92簇编码的MIR-20A可通过调节Fas表达提高骨肉瘤细胞的转移潜能

miR-20a Encoded by the miR-17–92 Cluster Increases the Metastatic Potential of Osteosarcoma Cells by Regulating Fas Expression

抗原特异性CD4 + T细胞可通过逆行MHC II类信号调节髓源性抑制细胞在癌症中的作用

Antigen-Specific CD4⁺ T Cells Regulate Function of Myeloid-Derived Suppressor Cells in Cancer via Retrograde MHC Class II Signaling

单核细胞CCR2 +的髓源性抑制细胞可通过限制性激活CD8 T细胞进入肿瘤微环境来促进免疫逃逸

Monocytic CCR2⁺ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment

Hedgehog信号抑制可通过影响肿瘤微环境阻断耐药肿瘤的生长

Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Molecular and Cellular Pathobiology

myc基因转录后可诱导正常细胞与癌细胞的HIF1蛋白与靶基因的表达

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells

p53介导的肿瘤内外双向乳酸通量可调控单羧酸转运蛋白MCT1

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

Prevention and Epidemiology

ATM和维生素D受体之间正反馈信号回路通过维生素D在癌症化学预防中发挥关键作用

A Positive Feedback Signaling Loop between ATM and the Vitamin D Receptor Is Critical for Cancer Chemoprevention by Vitamin D

Therapeutics, Targets, and Chemical Biology

适度上行通路激活可介导选择性BRAF抑制剂抗性

Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation

组蛋白去乙酰化酶抑制剂可提高胆碱激酶α和磷酸胆碱的水平从而便于对癌症患者进行无创性成像

Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

细胞周期检查点和CHK1，CHK2抑制剂AZD7762可增强新型拓扑异构酶I抑制剂茚并异喹啉LMP-400

Potentiation of the Novel Topoisomerase I Inhibitor Indenoisoquinoline LMP-400 by the Cell Checkpoint and Chk1-Chk2 Inhibitor AZD7762

Tumor and Stem Cell Biology

Ezrin蛋白磷酸化失调可预防骨肉瘤转移并改变其细胞代谢

Dysregulation of Ezrin Phosphorylation Prevents Metastasis and Alters Cellular Metabolism in Osteosarcoma

选择性切除乳腺c-Jun证实了其在mRNA剪接中的作用

Mammary Gland Selective Excision of c-Jun Identifies Its Role in mRNA Splicing

Hedgehog和Notch信号可调节未分化多形性肉瘤的自我复制

Hedgehog and Notch Signaling Regulate Self-Renewal of Undifferentiated Pleomorphic Sarcomas

Meeting Reports

第二十三届Pezcoller年度研讨会：癌症研究中模型工程的影响

Twenty-Third Annual Pezcoller Symposium: Engineering Influences in Cancer Research