中韩卒中血脂专家论坛-有关PCSK9I 证据,指南共识推荐

医脉通 2022.08.12

安进·安e学

11条内容

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参考文献:

1.Lau K K, Chua B J, Ng A, et al. Low‐Density Lipoprotein Cholesterol and Risk of Recurrent Vascular Events in Chinese Patients With Ischemic Stroke With and Without Significant Atherosclerosis[J]. Journal of the American Heart Association, 2021, 10(16): e021855. DOI:10.1161/JAHA.121.021855.

2.Chung J W, Cha J, Lee M J, et al. Intensive statin treatment in acute ischaemic stroke patients with intracranial atherosclerosis: a high-resolution magnetic resonance imaging study (STAMINA-MRI study)[J]. Journal of Neurology, Neurosurgery & Psychiatry, 2020, 91(2): 204-211. DOI: 10.1136/jnnp-2019-320893.

3.Masana L, Girona J, Ibarretxe D, et al. Clinical and pathophysiological evidence supporting the safety of extremely low LDL levels—The zero-LDL hypothesis[J]. Journal of clinical lipidology, 2018, 12(2): 292-299. e3. DOI: 10.1016/j.jacl.2017.12.018

4.Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)[J]. The Lancet, 1994, 344(8934): 1383-1389.

5.Cannon C P, Braunwald E, McCabe C H, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes[J]. New England journal of medicine, 2004, 350(15): 1495-1504. DOI: 10.1056/NEJMoa040583.

6.LaRosa J C, Grundy S M, Waters D D, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease[J]. New England Journal of Medicine, 2005, 352(14): 1425-1435. DOI: 10.1056/NEJMoa040583.

7.Ridker P M, Danielson E, Fonseca F A H, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein[J]. New England journal of medicine, 2008, 359(21): 2195-2207. DOI: 10.1056/NEJMoa0807646.

8.Nicholls S J, Puri R, Anderson T, et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA, 2016,316(22):2373-2384. doi:10.1001/jama.2016.16951

9.Nicholls S J, Kataoka Y, Nissen S E, et al. Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction[J]. JACC: Cardiovascular Imaging, 2022. DOI: 10.1016/j.jcmg.2022.03.002.

10.Sabatine M S, Giugliano R P, Keech A C, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease[J]. New England Journal of Medicine, 2017, 376(18): 1713-1722. DOI: 10.1056/NEJMoa1615664.

11.Giugliano R P, Pedersen T R, Saver J L, et al. Stroke prevention with the PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitor evolocumab added to statin in high-risk patients with stable atherosclerosis[J]. Stroke, 2020, 51(5): 1546-1554. DOI: 10.1161/STROKEAHA.119.027759.

12.Zhao, Z, Du, S, Shen, S, Luo, P, Ding, S, Wang, G, Wang, L. Comparative efficacy and safety of lipid-lowering agents in patients with hypercholesterolemia: A frequentist network meta-analysis. Medicine, 98, 2019. DOI: 10.1097/MD.0000000000014400.

13.Sanz-Cuesta, B.E. and Saver, J.L., 2021. Lipid-Lowering Therapy and Hemorrhagic Stroke Risk: Comparative Meta-Analysis of Statins and PCSK9 Inhibitors. Stroke, pp.STROKEAHA-121. DOI: 10.1161/STROKEAHA.121.034576.

14.Mach F, Baigent C, Catapano A L, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)[J]. European heart journal, 2020, 41(1): 111-188.

15.中国卒中学会. Chin J Stroke, 2019;14:594-9

16.Kleindorfer D O, Towfighi A, Chaturvedi S, et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association[J]. Stroke, 2021, 52(7): e364-e467. DOI: 10.1161/STR.0000000000000375.

17.Gil-Núñez A, Masjuan J, Montaner J, et al. Proprotein convertase subtilisin/kexin type 9 inhibitors in secondary prevention of vascular events in patients with stroke: Consensus document and practice guidance[J]. Neurología (English Edition), 2022, 37(2): 136-150.