刘希伶
中国医学科学院阜外医院深圳医院 ，
OBJECTIVE:To explore whether evidence-based nursing combined with cognitive function training can reduce the incidences of delirium in intensive care unit (ICU) patients and improve their cognitive function.METHODS:ICU patients in our hospital were randomly divided into an evidence-based nursing group (the E group) and an evidence-based nursing combined with cognitive function training group (the EC group). The incidences of delirium, the Pittsburgh Sleep Quality Index (PSQI) scores, the Mini-Mental State Exam (MMSE) scores, the National Institutes of Health Stroke Scale (NIHSS) scores, the Barthel Index levels, and the nursing satisfaction rates were compared between the two groups.RESULTS:Before the nursing, there were no significant differences in the MMSE scores, the NIHSS scores, the Barthel Index levels or the PSQI scores between the E group and the EC group (P>0.05). After one week of treatment, the incidences of delirium in the EC group were significantly lower than they were in the E group (P<0.05). The PSQI scores and the NIHSS scores in the EC group were significantly lower than they were in the E group (P<0.001). The MMSE scores and the Barthel Index levels in the EC group were significantly higher than they were in the E group (P<0.01). There was no significant difference in the nursing satisfaction rates between the two groups (P>0.05).CONCLUSION:Compared with using evidence-based nursing only, the combined application of evidence-based nursing and cognitive function training has a significantly better effect on the improvement of neurological function, sleep quality and normal living conditions in ICU patients.
American journal of translational research 2021
BACKGROUND:In this study, the whole exome sequencing in human aortic dissection, a highly lethal cardiovascular disease, was investigated to explore the aortic dissection-associated genes and variants in Chinese population.METHODS:Whole exome sequencing was performed in 99 cases of aortic dissection. All single nucleotide polymorphisms (SNPs), insertions/deletions (InDels), and copy number variations (CNVs) were filtered to exclude the benign variants. Enrichment analysis and disease-gene correlation analysis were performed.RESULTS:3425873 SNPs, 685245 InDels, and 1177 CNVs were identified, and aortic dissection-associated SNPs, InDels, and CNVs were collected. After the disease correlation analysis, 20 candidate genes were identified. Part of these genes such as MYH11, FBN1, and ACTA2 were consistent with previous studies, while MLX, DAB2IP, EP300, ZFYVE9, PML, and PRKCD were newly identified as candidate aortic dissection-associated genes.CONCLUSION:The pathogenic and likely pathogenic variants in most of AD-associated genes (FBN1, MYH11, EFEMP2, TGFBR2, FBN2, COL3A1, and MYLK) were identified in our cohort study, and pathogenic CNVs involved in MYH11, COL family, and FBN were also identified which are not detectable by other NGS analysis. The correlation between MLX, DAB2IP, EP300, ZFYVE9, PML, PRKCD, and aortic dissection was identified, and EP300 may play a key role in AD.
BioMed research international 2020
